Nova Biomedical- Hospital Based Blood Gas and Critical Care Analyzers

Up to 16 cell culture tests in one analyzer including chemistry, cdv, and osmolality
Nova Biomedical- Hospital Based Blood Gas and Critical Care Analyzers

11 chemistry tests with maintenance-free sensor card technology
Nova Biomedical- Hospital Based Blood Gas and Critical Care Analyzers

265 μL combined sample size
for full test menu

Automated Cell Culture Analyzer with Maintenance-Free Chemistry Sensors

BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. The full 16 cell culture test menu includes: Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++, pH, pCO2, pO2, total cell density, viable cell density, viability, cell diameter, and osmolality.

Compared to the previous generation BioProfile FLEX there is no maintenance for any of the 11 chemistry and gas sensors, sample volume for the full text menu is reduced by 75% to 265 microliters, and test time is reduced to just 4.5 minutes. Automated sampling from 96-well plates, syringes, or a 24-position external “load-and-go” sample tray provides maximum workflow flexibility and efficiency for cell culture monitoring.

Maintenance-free Microsensor Cards

Chemistry and gas biosensors are combined in the credit card sized MicroSensor Card, which uses proven Nova biosensor technology that has been validated in thousands of cell culture processes. MicroSensor Cards are maintenance-free, and replaceable in seconds.

Cartridge-based reagent management system (RMS)

FLEX 2’s RMS features smart reagent cartridges that are easy to use with simple snap-in replacement.
• RMS automatically captures cartridge installation date and time, lot number, and expiration.
• RMS monitors reagent usage and provides real-time reagent status and alerts, maximizing analyzer readiness.
• A self-contained waste receptacle within the cartridge eliminates direct handling of waste and direct contact with hazardous trypan blue and biological materials. Other systems can pose significant waste handling hazards to operators.

Fast analysis time

Comprehensive test results including cell density/viability, pH/gases, and key chemistries are available in 4.5 minutes. Throughput for individual modules is 2.0 minutes.

Small sample volume

Sample volume is 265 μL for a full 16-test profile, enabling comprehensive testing even from low volume culture systems. Individual modules require as little as 135 μL.

Analysis time and sample size when modules are run individually

Analysis time and sample size when all modules are run collectively

Maximum Workflow Efficiency

Simple touchscreen operation, a choice of three sampling modes, fast analysis time, and automated quality control (QC) provide maximum simplicity, labor savings, and workflow efficiency for cell culture monitoring.

Onboard automated quality control

Onboard liquid quality control (QC) provides true verification of FLEX 2 performance and saves hours of labor each week compared to manual QC testing. QC cartridges contain a 30-day supply of QC material. Controls are run automatically at user-selected intervals and QC data is automatically logged and filed in a variety of formats.

24-position, external load-and-go tray

An external load-and-go sample tray allows for continuous loading of cell culture samples for the most flexible and efficient sample throughput.

Automated, 96-well plate analysis

FLEX 2 is the only cell culture analyzer to offer automated sampling from 96-well plates. Any plate location can be configured for priority analysis. Plate configurations with mixed test panels may be saved, if future plates have the same configuration.

Syringe or cup sampling for critical analysis

Individual samples also can be analyzed directly from syringes or cups. Batch sampling via the 96-well plate and/or external “load-and-go” sample tray runs can be interrupted at any time to run critical gas syringe samples.


Advanced OPC Connectivity


21 CFR Part 11 Compliance